CHEM 212A ORGANIC
CHEMISTRY LABORATORY
FALL 2009
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Laboratory: |
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Instructor: |
Dr. Raymond Fong |
Office Hours: |
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Office: |
Science 236 |
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W 10:00 - 11:00 |
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Phone: |
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E-mail: |
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Chemistry 212A lab is the first semester of a one year course in organic chemistry required for chemistry/biochemistry majors.
Fulfills requirements for all medical schools and other health related graduate programs.
Prerequisite:
Chemistry 101B with a final grade of C or higher.
Required:
"Techniques in Organic
Chemistry", 2nd Ed., Mohrig,
Hardbound Laboratory Notebook
Safety Glasses and Calculator
Recommended:
Molecular Models
Resources: Computer Lab (S-205) - Spartan, Grams software, GC/MS software, and internet access. Copy of Aldrich catalog in labs, storeroom, and on reserve at the Library.
Grades: You will be graded in the laboratory on the basis of your laboratory reports, products, unknowns, laboratory notebook, and a lab final examination. You must pass both the lecture and the lab portion of the course to pass the class.
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Laboratory Experiments |
120 points |
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Lab Final |
30 points |
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150 points |
Your lab score will be normalized to
reflect the percentage designated by your lecture instructor.
Attendance: College regulations require that students be informed of attendance requirements for each course at the outset of the course. Any student who misses more than 3 successive meetings, or more than 5 class meetings, or 2 lecture tests, or 2 quizzes will be regarded as a non-participant and may be dropped.
Last day to DROP this course is
on
Assignments: For each chapter, read the assigned material and do the problem assignments. On occasion, I may give you additional problems to do. The intent of the problem assignments is only a suggestion. It will be for you to determine whether or not you need more practice on any given type of problem. If needed, you are expected to review any general chemistry when appropriate.
Reading assignments for the lab are in the laboratory textbook.
Some of the experimental procedures will be given in separate handouts and are part of the reading assignment.
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DATE |
EXPERIMENT |
READING ASSIGNMENT |
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August 18 |
Lab safety, notebooks, glassware, locker check-in handoutbook use |
pp. 1-38 |
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August 20 |
Melting/Boiling Points |
pp. 47-54, 116-130, |
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August 25 |
Melting/Boiling Points/Recrystallization |
pp. 100-112 |
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August 27 |
Recrystallization |
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September 1 |
Molecular Shapes and Modeling |
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September 3 |
Chemical Active Extraction |
pp. 75-86, 93-99 |
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September 8 |
Chemical Active Extraction |
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September 10 |
Optical Isomers/Stereoisomerism |
pp. 165-172 |
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September 15 |
Optical Isomers/Stereoisomerism |
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September 17 |
Distillation |
pp. 130-137, 142-145 |
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September 22 |
Distillation |
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September 24 |
Caffeine Extraction and Sublimation |
pp. 84-93, 158-160 |
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September 29 |
Caffeine Extraction and Sublimation |
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October 1 |
Thin Layer Chromatography |
pp. 177-189 |
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October 6 |
Column Chromatography |
Review extractions, pp. 206-219 |
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October 8 |
Column Chromatography |
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October 13 |
Hydroboration of 1-t-butylcyclohexene |
pp. 56-58, pp. 84-93 |
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October 15 |
Hydroboration of 1-t-butylcyclohexene |
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October 20 |
IR |
pp. 228-238, 243-262 |
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October 22 |
IR/NMR |
pp. 267-283, 294-311 |
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October 27 |
IR/NMR |
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October 29 |
NMR |
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November 3 |
Competing Nucleophiles |
pp. 190-205 |
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November 5 |
Competing Nucleophiles |
pp. 341-349, Review NMR use |
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November 10 |
Synthesis of Methyl Butenes |
Review Distillations |
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November 12 |
Synthesis of Methyl Butenes |
Review GC/MS |
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November 17 |
Synthesis of Triphenylmethanol |
Review microscale extractions and drying reagents |
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November 19 |
Synthesis of Triphenylmethanol |
pp. 240-241 |
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November 24 |
Open |
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December 1 |
H/D Exchange and Shift |
Review NMR and IR use |
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December 3 |
H/D Exchange and Shift |
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December 8 |
Laboratory Final Exam |
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December 10 |
Locker Check-out |
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You are required to read the laboratory material and experimental procedure before lab. In addition, you are required to have the following written in your lab notebook before the beginning of the lab:
1. Title and date of the experiment
2. Experimental Objective
3. Short outline of the procedure
4. Table of physical constants for organic chemicals used
molecular weight
melting point if chemical is a solid
boiling point if chemical is a liquid
density of liquid
hazards or dangers to be aware of
Grade for the course will determined by combining both lab total and the lecture total. Any changes in the lab schedule will be announced in advance. Lab reports are due one lab period after completion of the experiment. Points will be deducted for late lab reports.
All lab reports and lab notebooks will include the following:
1. Title and date of the experiment
2. Experimental Objective
3. Procedure: short outline of
the procedure. Also include any changes to the procedure.
4. Table of physical constants for organic chemicals used:
molecular weight
melting point if chemical is a solid
boiling point if chemical is a liquid
density of liquid
hazards or dangers to be aware of
5. Reaction and Mechanism (only for synthesis experiments)
6. Unknown Code if needed
7. Experimental Data and Observations - grams used, volume used, grams of product, etc.
8. Calculations: for example - moles used, theoretical yield, percent yield, etc...
9. Answers to any questions or problems assigned.
10. Conclusion of results and determination of unknown. A brief (no more than 1 page) summary of the relevant information for the experiment. What pre-cautions should be taken? What do your results tell you? How pure are your products? Explain results of any tests/analysis you performed. What functional groups or structural features of the starting materials were important in determining the outcome of the reaction? What is the mechanism? Try to account for any problems such as poor yields or impure products. Do not mention typical laboratory difficulties such as " Some solid left behing in the flask because I couldn't scrape it all out."
Poor lab technique will include the following: not wearing safety glasses or goggles in the lab, unprepared for the lab experiment, not finishing the experiment on time, not using your lab notebook to record data, and sloppy housekeeping.
Locker Check in/Locker Check out: You will check into a laboratory locker during the first day of classes. You will be responsible for all equipment in the locker. If you should drop, withdrawal, or take a leave of absence from the course, you must also check out of the locker. If this is not done, there will be a HOLD placed on next semester's registration and all records at CCSF.
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